Current Lab Members
Cerebral Cortex; Congenital Abnormalities; Mental Disorders Diagnosed in Childhood; Neurobiology; Prenatal Diagnosis
My research is focused on transcriptional and regulatory programs that precisely orchestrate the formation of the neocortex. Disruption of these mechanisms cause neurological and psychological disorders. I apply a systems biology approach in combination with molecular genetics to decipher both conserved and species-specific developmental mechanisms.
I am interested in studying molecular mechanisms of cortical developmental malformations in neurodevelopmental disorders and psychiatric diseases. By establishing animal models of human brain disorders and recruiting variety of molecular biology, genetic, morphology as well as transcriptomics methods, I hope my study will facilitate understanding the basics of neuopsychiatric diseases and developing time efficient therapeutic strategies.
Central Nervous System; Neurodegenerative Diseases
Many years of experience in
worldwide laboratories (Russia,
lend to expertise in the methods of scanning and transmission electron
microscopy including pre- and post-embedding immunolabeling. This also let me
introduce to Yale the method of three-dimensional reconstruction of large cell
fragments such as neuron cell bodies or processes from serial electron
Anatomy; Brain; Cell Biology; Chemicals and Drugs; Disorders of Environmental Origin; Embryo Research; Embryology; Fetal Research; Genetic Research; Nervous System Malformations; Neurogenesis; Neurosciences; Optogenetics; Stem Cells
My interests in cerebral cortex development emerged from studies of axon guidance of the corpus callosum while a post-baccalaureate student at the University of Maryland, Baltimore. This work turned into a masters thesis as I began doctoral studies at the University of Chicago in the field of telencephalic patterning. The formation of the mammalian brain is one of the most fascinating subjects in science and I decided to continue this line of research with post-doctoral studies of brain...
Summary of Research and Future Directions: My interest is in how neurons change their connectivity and structure during the "critical period" of development and how this may be applicable to human disorders. Currently, I am investigating the possibility of inducing critical period-like synaptic plasticity in an adult
I am interested in developmental dynamics, i.e. changes to the neural stem cell niche as development proceeds through time. I am interested in neural molecular identity, differentiation, and cell fate restriction in early cortical progenitors. My thesis work focuses on the interactions between both novel and well-established transcriptional regulators in cortex development.