Current Lab Members
Cerebral Cortex; Congenital Abnormalities; Mental Disorders Diagnosed in Childhood; Neurobiology; Prenatal Diagnosis
My research is focused on transcriptional and regulatory programs that precisely orchestrate the formation of the neocortex. Disruption of these mechanisms cause neurological and psychological disorders. I apply a systems biology approach in combination with molecular genetics to decipher both conserved and species-specific developmental mechanisms.
Central Nervous System; Neurodegenerative Diseases
Many years of experience in
worldwide laboratories (Russia,
lend to expertise in the methods of scanning and transmission electron
microscopy including pre- and post-embedding immunolabeling. This also let me
introduce to Yale the method of three-dimensional reconstruction of large cell
fragments such as neuron cell bodies or processes from serial electron
Anatomy; Brain; Cell Biology; Chemicals and Drugs; Disorders of Environmental Origin; Embryo Research; Embryology; Fetal Research; Genetic Research; Nervous System Malformations; Neurogenesis; Neurosciences; Optogenetics; Stem Cells
My interests in cerebral cortex development emerged from studies of axon guidance of the corpus callosum while a post-baccalaureate student at the University of Maryland, Baltimore. This work turned into a masters thesis as I began doctoral studies at the University of Chicago in the field of telencephalic patterning. The formation of the mammalian brain is one of the most fascinating subjects in science and I decided to continue this line of research with post-doctoral studies of brain...
Summary of Research and Future Directions: My interest is in how neurons change their connectivity and structure during the "critical period" of development and how this may be applicable to human disorders. Currently, I am investigating the possibility of inducing critical period-like synaptic plasticity in an adult
I am interested in developmental dynamics, i.e. changes to the neural stem cell niche as development proceeds through time. I am interested in neural molecular identity, differentiation, and cell fate restriction in early cortical progenitors. My thesis work focuses on the interactions between both novel and well-established transcriptional regulators in cortex development.