Brian Grayson Rash, PhD

Associate Research Scientist in Neuroscience

Biography

The primary goal of my research is to investigate the cellular, genetic, and environmental mechanisms of cognitive neurodevelopmental disorders. The environmental component of this risk is prominent during embryonic development, and is key to our understanding of avoidable risks to brain development. I utilize a wide variety of approaches including state-of-the-art optogenetic and computational methods to study how cortical stem cells, known as radial glial cells (RGCs), proliferate and differentiate into post-mitotic neurons. We are uncovering key subcellular dynamics of RGCs which are important for cortical growth and circuit formation (see Rash BG et al., 2016, Science Advances). Current research aims to determine the subcellular calcium dynamics of RGCs, their relation to mitochondrial and cytoskeletal activity, and how this regulates fundamental processes in cerebral cortex development, such as neurogenesis and the migration of newborn neurons out of the stem cell niche. Understanding how these processes can be disrupted by environmental/maternal factors, including metabolic disorders and the usage of medications or other drugs during pregnancy, will be important in the prevention of childhood neurological disorders.

Education & Training

PhD University of Chicago (2007)
Associate Research Scientist Yale University
Post-Doctoral Fellow Yale University

Honors & Recognition

  • James Hudson Brown — Alexander Brown Coxe Postdoctoral Fellowship in the Medical Sciences Yale University (2009)

  • Dissertation Prize for outstanding performance in the field of Neurobiology, University of Chicago.Committee on Neurobiology (2008)

  • T32 Fellowship, Child Study Center, Yale UniversityYale University (2007)

Professional Service

  • Journal of Neurodevelopmental Disorders (2013 - 2014) Official Peer Reviewer

  • Proceedings of the National Academy of Sciences (2012 - 2015) Official Peer Reviewer

  • Cerebral Cortex (2012) Official Peer Reviewer

  • Journal of Child Psychology and Psychiatry (2010 - 2011) Official Peer Reviewer

Activities

  • Columnar organization of calcium dynamic activity during cortical development Trondheim, Norway (2013 - 2013)

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Contact Info

Brian Grayson Rash, PhD

Curriculum Vitae