Morphogenic gradients governing areal identity in the neorcortex

Graded expression patterns of several factors thought to be responsible for shaping the ultimate neocortical landscape that is highly partitioned and specialized. Supplement list to Figure 4 in Rakic P, Ayoub AE, Breunig JJ, Dominguez MH. Decision by division: making cortical maps. Trends Neurosci. 2009 May;32(5):291-301. Epub 2009 Apr 18. Review. PubMed PMID: 19380167.

ImageMoleculeRepresssesInducesRepressorsInducersReferences
BMPs (4,6,7; also 2,5)Foxg1, FGF8Msx1FGF8, NogginPubmed
Cadherin-11Pubmed
Cad6Cadherin-6FGFsPubmed
CAd8Cadherin-8FGFsPubmed
Clim1aClim1aPubmed
COUP-TFICOUP-TFI (Nr2f1)FGF8 > FGF17Pubmed
EGFsEGFs (TNFalpha, Nrg1, Nrg2, Nrg3)Pax6 (required)Pubmed
Emx2Emx2FGFs, Pax6ReelinFGF8 >>> FGF17, Pax6WntsPubmed
EphA2EphA2Pubmed
EphA7EphA7Pubmed
Ephrin-A5Ephrin-A5FGFsPubmed
Etv1Etv1(Er81)FGF8Pubmed
FGF15FGF15Pubmed
FGF17FGF17Sp8Sp8Pubmed
FGF8FGF8BMP4, Wnts, COUP-TF1, Emx2, Otx2FGFs, Sp8, Nkx2.1, Ets Factors (Pea3, Erm, Etv1), Spry1 and Spry2Emx2Shh, Sp8Pubmed
FGFR3FGF8Pubmed
Foxg1Foxg1 (BF1)BMPsBMP2, BMP4, WntsPubmed
Id2Id2Pubmed
Lhx2Lhx2WntsPubmed
Lmo3Lmo3Pubmed
Lmo4Lmo4Pubmed
Nt3Nt3Pubmed
Otx2Otx2FGF8Pubmed
p75p75Emx2Pubmed
Pax6Pax6Emx2sFrp2Emx2Pubmed
Pea3FGF8Pubmed
RORbetaRORbetaFGFsPubmed
SCIPSCIP (Pou3f1)Pubmed
sFrp2Sfrps (sFrp2)WntsPubmed
ShhGli3FGF8, Gli3RNkx2.1Pubmed
Sp8Sp5Pubmed
Sp8FGF8FGFsPubmed
 Spry1Ets factors??Pubmed
Tbr1Tbr1FGF8Pubmed
Wnts (Wnt3a,Wnt2b,Wnt5a,Wnt8b)FGFsNOT BMPPubmed